MCDB 418 Chapter Notes - Chapter 17: Rickets, Menopause, Osteoporosis

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Cofactor for enzymes, ex: blood clotting (w/o calcium, will bleed forever) It"s compartmentalized (inside and outside of cell are different) Seldom changes form 1. 25mm in blood, in basal condition 0. 1 micromolar inside cell. Half is free, half is bound (such as to albumin) Must get from outside through eat or drink intestinal tract, about half gets absorbed into blood. Net gain is about 200mg kidneys - urine can excrete calcium (balances the 800 coming in) 98% deposited in bone, every ten years entire bone will be replaced. *will be tested on: absorption, reabsorption, and resorption. Absorption: in intestine, import calcium from outside body, into own body, using intestine epithelial cells, two major pathways (paracellular between cells (high ca con"c) so diffusion process, transcellular through cell ([low ca]), happens against gradient), Trpv6 (selective transport): calcium selection channel, lumen side, into cell binds to calbindin which moves ca to other side of cell, two pumps on this side.

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