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Chapter 22

CHEM 242 Chapter 22: Chapter 22


Department
Chemistry
Course Code
CHEM 242
Professor
Jisun Lee
Chapter
22

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Chapter 22 Condensations and Alpha Substitutions of Carbonyl Compounds
Enols and Enolate Ions (pg 1047):
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-Formation and stability of enolate ions:
Sometimes this equilibrium mixture of enolate ad ase wo’t work, usuall eause the ase (hdroide or
alkoxide) reacts with the electrophile faster than the enolate does. In these cases, we need a base that reacts
completely to convert the carbonyl compound to its enolate before adding the electrophile. The most
effective and useful base for this purpose is lithium diisopropylamide (LDA), the lithium salt of
diisopropylamine:
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Alkylation of Enolate Ions (pg 1050):
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