NURS-UL 3365 Chapter Notes - Chapter 2: Therapeutic Drug Monitoring, Trough Level, Drug Metabolism
28 Jan 2020
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Cytochrome p-450: enzymes for drug metabolism and interactions. First-pass effect: metabolism in the liver reaching circulation. G6pd: red blood cell breakdown when the body is exposed to drugs. Medication use process: prescribing, dispensing, administering and monitoring drug effects. Onset of action: time of response after dosing. P-glycoprotein: moves drugs out of the gut, urine, and bile. Peak effect: time required to reach maximum therapeutic response. Peak level: maximum concentration of a drug in the body after administration. Steady state: amount removed is equal to amount absorbed. Synergistic effects: drug interactions in which the effect of a combination of two or more drugs with similar actions is greater than the sum of the individual effects of the same drugs given alone. Therapeutic drug monitoring: measuring drug levels to maximize therapeutic effects and minimize toxicity. Trough level: lowest concentration after falling from peak level.
