BIOL 3050 Chapter 11-12: biol ch. 11&12:lecture

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erinzebra747

14 Jul 2016

School

University of Virginia

Department

Biology

Course

BIOL 3050

Professor

Condron Barry

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Document Summary

Review: pathways mediating discriminative aspects of pain and temperature for the body and face: 1: in dorsal horn of spinal cord, pain sensing neurons activate interneurons that go up to brain + Oct 1, 2015 to experience pleasure (internal high) Cataract (dissect out and put in new lens : vitreous humor inert substance; oaters can occur here, fovea most sensitive part of the retina, refractive errors, emmetropia (normal, myopia (nearsighted) develops around 15-20 years old. 2: hyperopia (farsighted) lens won"t relax so can"t focus on objects close to you; develops with. = ~ 30 hz 30 frames/second (this rule is actually broken so often! Get stem cells to re-generate photoreceptors or wire into lgn: connection to superior colliculus is not through. 5: visual eld, retinal eld and elds how they appear in the cortex (broken down into parts that one.

Related Questions

A 62 year old man sudden developed an ataxic gait, and he tended to fall to the right. His right arm and leg became clumsy and he became hoarse. When he was asked to stand with his feet together, he tended to fall to the right, whether his eyes were open or closed. The right eyelid drooped, and the right pupil was distinctly smaller than the left. He did not sweat on the right side of his face. Pain and temperature sensations were decreased on the right side of the face and over the left side of the body and left limbs.

A) where in the central nervous system was the lesion? What was the cause of the somatic sensory deficits?

B) what was the cause of the autonomic changed in the right eye and face?

C) what was the mother disorder affecting gait? Why did he become hoarse?

1.All peripheral sensory input enters the spinal cord through the 2.Mechanoreceptor afferents are divided into two main classes based on(Points : 2) 3.Branches of SAI afferents terminate in ____________ where they are proposed to be the site of ____________ transduction.(Points : 2) 4.SAI afferents appear to be used by the CNS to perceive(Points : 2) 5.AII afferents have ________ receptive fields and greater sensitivity to ________ than do SAI afferents.(Points : 2) 6.Somatosensory afferents from the muscle are sensitive to ___________ while afferents from the tendon are sensitive to ___________.(Points : 2) 7.Kinesthesia is obtained by convergent afferents of the muscles, tendons, joints and___________8.Nociceptors respond to ________ stimuli and sense through use of ___________.(Points : 2) 9.First pain is transmitted through ______ receptors that carry discriminative information, and second pain is modulated by _______ receptors.(Points : 2) 10.Acute skin damage is accompanied by ____________ that is the result of local activation of nociceptors leading to ________.(Points : 2) 11.Somatic sensation retains separation of mechanosensation and __________ from nociception and ___________ which is evident from PNS to CNS.(Points : 2)12.The primary somatosensory cortex has ventral projections to(Points : 2) 13.The dorsal stream of the somatosensory cortex project to(Points : 2) 14.The dorsal column nuclei are located(Points : 2) 15.The lateral cervical nucleus is located in the ____________ and display ___________ receptive fields.(Points : 2) 16.Non-perceptual input of nociceptors influence behavior by(Points : 2)17. sensory trigeminal system is composed of the...18.The receptive fields of secondary somatosensory cortical neurons are ___________ than those of the primary somatosensory cortex.(Points : 2) 19.Receptive fields in the primary somatosensory cortex are(Points : 2)I really need help with this please! The person who is able to help me with the CORRECT answers will be compensated with 3000 points! This assignment will be graded instantly by a computer so I will know if the person actually tried or if they just put in some crazy answers just to get the points. The points will be rewarded IMMEDIATELY after the assignment is graded, which, as I stated above is done instantly by the computer once submitted. At least 75 to 80% of the questions must be correct in order to receice all 3000 points today. Thank you SO much in advance!!! :)

pucereindeer600

Homozygosity for extremely rare mutations in a human gene called SCN9A cause complete insensitivity to pain (congenital pain insensitivity or CPA) and a total lack of the sense of smell (anosmia). The SCN9A gene encodes a sodium channel protein required for transmission of electrical signals from particular nerves in the body to the brain. The failure to feel pain is a dangerous condition as people cannot sense injuries.

The SCN9A gene has 26 exons and encodes a 1977-amino acid polypeptide. Consanguineous matings in three different families have resulted in individuals with CPA/anosmia. In Family 1, a G-to-A transition in exon 15 results in a truncated protein that is 898 amino acids long; in Family 2, deletion of a single base results in a 766-amino acid polypeptide; and in Family 3, a C-to-G transversion in exon 10 yields a 458-amino acid protein.

a. Hypothesize as to how each of the three SCN9A mutations affects gene structure: Why are truncated proteins made in each case?

b. How would you classify the mutant alleles? Do these cause loss of function or gain of function? Are they amorphs, hypomorphs, hypermorphs, neomorphs, or antimorphs?

c. Explain in molecular terms why CPA/anosmia is a recessive condition.

BIOL 3050 Chapter 11-12: biol ch. 11&12:lecture

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