HBS204 Lecture Notes - Lecture 9: Guanylyl Cyclase, Adenylyl Cyclase, Protein Kinase C

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7 Apr 2020
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2 second messenger signalling molecules camp (& cgmp) and ip3/dag. 2 other important signalling molecules calcium and nitric oxide. It follows the classic second messenger pathway - you get a g-protein-coupled receptor that binds to a signalling molecule, the g-protein then activates an amplifier enzyme, in this case the enzyme is. Adenylyl cyclase: adenylyl cyclase makes cyclic amp - which activates a target protein - protein kinase a which goes on and phosphorylates a number of target proteins of a zone and then you get a cellular response. Cyclic gmp (cgmp: another second messenger system, similar to cyclic amp, it has different cellular effects but has a very similar system and it is identical other than the fact that you replace all the a"s with g"s. Instead of adenylyl cyclase, it is guanylyl cyclase and you produce cyclic gmp rather than cyclic. Amp and more often then not, it activates protein kinase g rather than protein kinase a.

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