HBS204 Lecture Notes - Lecture 4: Proximal Tubule, Potassium Chloride, Electrochemical Gradient

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7 Apr 2020
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Hbs204 week 4 the renal system 2. Generally, 99% of the solute and water that is filtered is reabsorbed into the blood. The short answer is that filtering fluid from the blood so frequently gives our body a great ability to rapidly remove wastes and constantly fine tune the constituents of the extracellular fluid (e. g. maintain appropriate solute/water balance). Sodium and many other solutes like glucose, chloride and water and freely filtered and freely cross the filtration membrane, but most of it is reabsorbed. The filtration membrane is comprised of the glomerular endothelium, basal lamina and podocyte end feet. Sodium reabsorption is an active process and primarily occurs in the proximal tubule and governs the reabsorption of many other solutes. The concentration of sodium in the filtrate is the same as it is in the plasma, we only excrete a small percentage of the sodium therefore much of what is filtered is reabsorbed back into the circulation.

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