MICR3002 Lecture Notes - Lecture 3: Reverse Transcriptase, Endosome, Endocytosis
Document Summary
Lecture 3 and 4 rna and dna viral replication. Drug targets are specifically designed to inhibit transcription and replication. Understand the methods that viruses use to do this is vital to develop viral drugs (eg. hpc) Viral genomes are heavily condensed to maximise gene coding capacity. They overlap genes, employ different reading frame, utilise both strands and either don"t contain or contain very few non-coding regions as they do not have the space to do so. Rna genomes: generally smaller (max of 30kb: eg. coronavirus) due to viral rna polymerases being much more error prone. Class i: dsdna, uses the same strategy as the host for replication, transcribes from the (-) strand, example: pox virus. Class ii (+) ssdna: same as class i, but must make the genome into a ds molecule first, to form the (-) strand for transcription, example: parvovirus.
