MICR3002 Lecture Notes - Lecture 1: Cell Membrane, Peptide, Polyadenylation
Document Summary
Insect viruses: no alternate host, found in many virus families, true insect virus (infects only insects) Many virus families include insect viruses: some contain both insect viruses and others, eg. Poxviridae have strains that infect different types of hosts (interesting with evolutionary context: some are only found in insects/invertebrates, eg. Viruses use and compete for host translational machinery. If there is limited availability of resources, the virus wants energy expenditure for itself: the virus will interfere with the innate immune response that comes from translated proteins. Host antiviral mechanisms aims to shutdown translation, but viruses have evolved unique mechanisms to control the host translation of viral proteins: this combats the issue of viral translocation being dampened due to a decrease in host translation. Structural proteins are at the 3" end of the genome. Polyproteins are cleaved by proteases to produce final protein products (which is controlled by the virus)
