MICR3002 Lecture Notes - Lecture 3: Reassortment, Genetic Drift, Respiratory Tract
Document Summary
Adaptive immunity is too slow to protect against initial infection. Pathway: prr recognise pamps, adapter molecules, kinases, activation of ifn tfs, transcription and secretion of ifns, alpha, beta, lambda, gamma, transcription and secretion of cytokines. Inflammatory response: apoptosis, attraction of other cell types, activation of jak/stat pathway. Amplification of ifn and induction of antiviral isgs. Interferons: type 1: ifn-alpha and ifn-beta produced by most cells. Interact with ifnar (receptor: usually epithelial cells and pdcs, production of antiviral factors in infected cells (autocrine, production of an antiviral state in uninfected cells (paracrine, type 3: ifn-lambda produced by most cells, usually epithelial cells. Interact with il-28r (receptor: note: type 1 and 3 give similar responses, but different receptors induce different antiviral proteins, type 2: ifn-gamma produced by t and nk cells, recognise infected cells. Interact with ifngr (receptor: signalling occurs via jak-stat pathway.
