IMED2004 Lecture Notes - Lecture 7: Morphogen, Pattern Formation, Zygote
25 Mar 2020
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Document Summary
The role of genes in pattern formation: what a cell can do is largely determined by the proteins in it. In development we are concerned with those proteins that make cells different from one another tissue-specific genes: genes control development by specifying which proteins are made in which cell and when, proteins make it different. 3 axes of the body: anterior-posterior, ventral-dorsal (front to back, left-right. Model to understanding embryo patterning in drosophila: shows different embryonic development compared to vertebrates but why is it useful for wider studies of development, many developmental genes in vertebrates (e. g. hox genes) identified in drosophila first. We are able to imagine and study and get lots of information and we can apply it to us: demonstrates many general principles of development conserved across animals. Pattern formation: experimentally very powerful for hypothesis testing. Fully sequenced genome: much more simple. In drosophila- anterior-posterior axis: determined by gradients of. Bicoid (product of the gene of bicoid)
