IMED2004 Lecture Notes - Lecture 31: Vinca Alkaloid, Targeted Therapy, Pancreatic Cancer
26 Mar 2020
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Document Summary
Intrinsic mechanisms exist to prevent cancer: cancer cells overcome these defences step by step, 8 hallmarks of cancer, cancer is a progressive process - acquisition of a series of mutations. Multiple mutations are necessary for cancer progression: tumours must also co-opt the microenvironment, including evasion of the immune response. Evolution of cancer treatments: originally surgical - excision or debulking slash, radiotherapy - ~100 years old burn, chemotherapy drugs - developed in the 1940-60s burn, biological therapies - b/m transplants, targeted therapies - since 1990s. Survival with chemotherapy: while traditional chemotherapy has severe side effects , survival rates have in many cancers, especially paediatric cancers, leukaemia and lymphoma, e. g. paediatric all & hodgkin"s lymphoma. Targeted therapies in cancer: treatments targeting oncogene driven signalling pathways, using treatment of adult leukaemias to illustrate the mix of old and new therapies. Leukaemia in adults: very different profile to paediatric leukaemia, different cytogenetics, presentations & treatment, today"s lecture - treatment of, aml, cll, cml.
