IMED2004 Lecture Notes - Lecture 32: Megaloblastic Anemia, Bone Marrow Suppression, Nitrogen Mustard
26 Mar 2020
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Initially developed to treat leukaemia & lymphoma: used in combination with surgery, radiotherapy and biological therapy (b/m transplants etc. ) Iv drug efficacy and tumour regrowth - cure vs remission: v cell cycle and susceptibility to specific drugs, vi drug resistance - next lecture. I - specificity of cancer drugs: tumour cells are characterised by uncontrolled growth, traditional chemotherapeutic drugs act on growing cells - anti-proliferative tumour growth (cytotoxic) But highly proliferative normal tissues are poisoned too: gi tract epithelial cells, hair follicles, bone marrow/haematopoeitic cells, side effects include, gi toxicity hair loss (alopecia, myelosuppression - infection, anaemia, bleeding. Ii - kinetics of tumour growth & detection: a tumour is usually relatively far advanced when diagnosed. Iii drug efficacy & proportional killing: a given dose of chemotherapy kills a fixed proportion of tumour cells (<100%), not a fixed number of cells.
