BIOL 462 Lecture 4: BIOL 462 Lecture 4
18 Feb 2019
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Document Summary
Tlr-like (and other) domains for binding to na, proteins. Can also sense changes in intracellular environment: activates caspase-1 protease, caspase-1 cleaves and activates il-1/il-8. Card gives them the ability to possibly interact with caspases. Card domain many activate caspase 1 which is important to release il-1 and 18 which are important to the inflammatory pathway. Nod oligomerization may lead inflammasomes need a second trigger from complete activation (k+ flux, ros) Inflammasomes can be triggered by daps (e. g. , hyaluronan, lysosomal components, -amyloid. Polymers of the receptors - necessary to begin to produce il caspase activities. Aka get lots of caspase in one place so they can cleave lots of il precursors. Activation of cells by lps induced the formation of large multiprotein aggregate containing an nlr and. 1 mature caspase-1 that cleaved pro-il-1 into mature il-1, allowing its release from cells (they then called this the inflammasome) A way that pathogens are targeted by innate: mbl.
