HTHSCI 3I03 Chapter Notes - Chapter 3: Pattern Recognition Receptor, Nalp3, Caspase 1

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 3I03
• Professor: Jonathan Bramson

Document Summary

(4) innate immunity iii: pathogen recognition and induction of innate. The innate immune system seeks out danger signals, which can be external (pamps) or internal (damps) The innate immune system recognizes pamps or pathogen-associated molecular patterns (an external danger) by a limited number of receptors. Pamps include lipoteichoic acids, which is the major constituent of gram + bacterial cell walls and lipopolysaccharides (lps) on the outer membrane of gram bacteria. Common features of pamps: produced only by microbial pathogens, not their hosts, are essential for the survival and pathogenesis of microorganisms, typically invariant structures shared by the entire class of pathogens. Tissue injury or stress causes the release of nuclear or cytosolic proteins from the damaged cells into the intercellular space. These molecules can be the non-infectious source of inflammation and are known as danger-associated molecular patterns (damps) Receptors of the innate immune system: phagocytic receptors and prrs.