ANAT 262 Lecture Notes - Lecture 9: Stress Granule, Nup98, Peroxisome
15 Jul 2016
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Document Summary
Large numbers of proteins that are related to diseases and important for trafficking. Cas: exporter for importin-a, related in cancer (overexpression) Egfr: usually in the pm but it can also translocate into the nucleus depending on what the therapy the patient gets. Many of the anti-cancer drugs induce dna damage to kill the cancer. Egfr hence plays a role in drug resistance that we see in patients. Established proteins that traffic to nucleus plays an important role in diseases development (viral proteins, or related to cancer) Many of these factors play a role unrelated to nuclear trafficking: transcription, stress response etc. Compartment in the cytoplasm which are formed when a cell is exposed to stress (oxidative stress, anti-cancer drug stress). When translation initiation is inhibited, this is a signal to form stress granules containing large number of proteins. Stress granules contain unique proteins induced by stress and p-bodies which are involved in mrna turnover.
