MIMM 214 Lecture Notes - Lecture 9: Titer, Mhc Class I, Apoptosis
15 Mar 2017
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Document Summary
Fate-specifying cytokines: induce differentiation of different cell types; then leads to production of different cytokines, by these differentiated cell types. Local inflammation: macrophages activated in tissue, secrete tnf- into tissue. Systemic: macrophages activated in liver & spleen, secrete tnf- into. Blood infection of bacteria => sepsis => death. C-reactive protein can opsonize; can trigger classical complement cascade. The good: complement; blood flow up (vasodilation); migration of cells to site of infection; increased body temp. will worsen environment for pathogen; physical sign that alerts the patient. Both ilcs (innate lymphoid cells) and nk cells derive from common lymphoid progenitor. Activated by cytokines; then secrete cytokines to contribute to pathogen killing (indirect cytokine signal effect; unlike nk cells which kill directly) Nk cells: in tissues, or in circulation -- directly kill cells. Like ilcs, are lymphoid cells with innate immune functions. Do not need to know names of these receptors but need to differentiate b/w activating and inhibitory receptors.
