MIMM 214 Lecture Notes - Lecture 4: Lepromatous Leprosy, Tuberculoid Leprosy, Mhc Class Ii
5 Jan 2019
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Humans have ~25 000 genes but billions of antigens. Dna shuffling is essential to antigen recognition (ikea models) Each antigen receptor clone on a lymphocyte has a single specificity. Once antigen is introduced, one of the clones will recognize antigen and will beginning proliferating and differentiating. This is the clonal theory of adaptive immunity. Programmed cell death or apoptosis after immune response. Two types of pathogens = two main types of adaptive. Extracellular pathogens humoral immunity (ab- mediated) The cytokine environment promoting cellular responses is primarily determined by cytokines from the activated t- cells along the th1 profile. The cytokine environment promoting humoral responses is primarily determined by cytokines from the activated t- cells along the th2 profile. Patient has little to no disease resulting in benign tuberculoid leprosy. Th2 response results in massive production of antibodies that never reach bug because it lives in cells. Results in massive disfiguration due to nodules from lepromatous leprosy.
