MIMM 214 Lecture Notes - Lecture 21: Ccl2, Critical Role, Leukocyte Extravasation
15 Mar 2017
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Cell-mediated immunity: th1 cytokines promote tc killing & macrophage ros killing. Important for response to intracellular bacteria (e. g. m. tuberculosis & salmonella) & protozoa (e. g. Important for response to intracellular bacteria (e. g. m. tuberculosis & salmonella) & protozoa (e. g. leishmania & toxoplasma: so, th1 responses are really important for clearing intracellular bacteria. Th1: signal 3 & effector cytokine: the signal 3 that tell na ve cd4+ t cells to differentiate into th1 cells consists of ifn-gamma and il- 12 as mentioned above: these cytokines impact the differentiation of t cells, the differentiated effector t cells then secrete its own cytokines, ifn-gamma. Transcription factors to induce transcription of specific genes lymph. Its function is to aid in killing of microbes that persist in macrophage vesicles. Activated m1 macrophage (classically-activated macrophage) the tcr which binds ifn- Macrophages play a critical role in clearing intracellular bacteria and protozoa.
