MIMM 214 Lecture Notes - Lecture 30: Complement Membrane Attack Complex, Memory T Cell, Fragment Crystallizable Region
23 Mar 2017
School
Department
Course
Professor
Document Summary
When the b cell receives a cytokine signal (and cd40l) from the t cell, transcription is activated upstream of the constant region this does not result in productive mrna. The b cell already has vdj recombination (done in the bone marrow) and has just successfully undergone some somatic hypermutations but it still contains on its genomic dna all of the various heavy chain constant regions. Upstream of each of the constant regions there are switch regions. Aid in activity of granulocytes trigger degranulation. Transport different abs are targeted to different regions of the body. Igs opsonise, act on cells and get across them via interaction with the fcr. Aggregation of binding can allow crosslinking of fcrs triggers intracell signaling. Fcr (green) bound to ab (yellow) which is not bound to ag. In the lower panel, we see two abs binding adjacent fcrs and they are bound to a bacterium.
