MIMM 214 Lecture Notes - Lecture 29: Phagocytosis, Immunoglobulin G, Mucus
7 Jun 2018
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Lecture 30 – March 22, 2017
Class switch recombination
- When B cell receives cytokine signal, transcription is activated upstream of constant region
o This does not result in productive mRNA
- DNA is now accessible to AID
o Because it has opened up for transcription
o
- Nicks are made on both DNA strands
- Double strand breaks in DNA upstream of constant region to be recombined
- DS break repair machinery repairs break by cutting out the intervening DNA
- Selected region now adjacent to VDJ region
- Switch regions
o Low transcription from this
o No functional mRNA
Recap
Overview of Antibody Functions
Each Ig class and subclass has specialized function
- Antibodies mediate the clearance and destruction of pathogen in a variety of ways
- Each Ab isotype has distinct properties and traits that enable it to do so
Key antibody functions
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
When b cell receives cytokine signal, transcription is activated upstream of constant region: this does not result in productive mrna. Dna is now accessible to aid: because it has opened up for transcription. Nicks are made on both dna strands. Double strand breaks in dna upstream of constant region to be recombined. Ds break repair machinery repairs break by cutting out the intervening dna. Recap: low transcription from this, no functional mrna. Each ig class and subclass has specialized function. Antibodies mediate the clearance and destruction of pathogen in a variety of ways. Each ab isotype has distinct properties and traits that enable it to do so. Family of cell surface receptors that bind to the fc portion of igs: expressed on macrophages, granulocytes, dcs, mast cells, b cells, epithelial cells, bi(cid:374)d igs i(cid:374) a (cid:272)lass spe(cid:272)ifi(cid:272) (cid:373)a(cid:374)(cid:374)er (cid:894)e. g. f(cid:272)ga(cid:373)(cid:373)ari (cid:271)i(cid:374)ds igg1, f(cid:272)epsilo(cid:374)ri (cid:271)i(cid:374)ds ige (cid:895)
