PHGY 313 Lecture Notes - Lecture 1: Innate Lymphoid Cell, Lamina Propria, Lymphatic System
24 May 2016
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Phgy 313-fritz 1: immunology of gi system: structure and leukocyte function of the gut. Unique features of mucosal immune system o o. Close association of mucosal epithelial layers and lymphoid structures. Iga, t cells that activate even without infection. Systemic immune system = largely sterile environment, vigorous response to microbes. Mucosal immune system = constant exposure to foreign matter. Galt (gut): peyer"s patches (pp), lamina propria (lp), isolated lymphoid follicles (ilf), cryptopatches (cp) o. Genital tract: not as clear, no lymphoid follicles o o. Prototypical mucosal surface: gut: o o o o. Rich in b cell follicles, smaller t cell areas. Surrounded by epithelium interspersed with microfold (m) cells. More exposed you are to antigens, the bigger your peyer"s patches! Goblet cells produce mucous (thick barrier that covers the gi epithelium, prevents easy access) o. Pathogens become trapped in mucous, expelled vial peristalsis. Mucous also acts as reservoir for secretory iga: epithelial tight junctions.
