BIOCHEM 2EE3 Lecture Notes - Lecture 7: De Novo Synthesis, Lactate Dehydrogenase, Carbohydrate Metabolism

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General overview: glucose is broken down sequentially through glycolysis then through the pyruvate dehydrogenase reaction and citric acid cycle . Recall that vertebrates store glucose in the form of glycogen. Glycogen: is a highly branched structure with a single reducing end and several nonreducing ends. strucuture. The alpha-1,4 bonds link the glucose subunits linearly, while the alpha1,6 bonds form the branch points. Glucose residues are sequentially removed from several non-reducing ends during glycogen degradation simultaneously, providing a rapid surge of glucose release when it is needed by the body. ( at high exercise intensity ) Like atp, utp can be used as an energy source: activated by high concentrations of glucose-6-phosphate. We will focus on the key enzymes in metabolic pathways that regulate the overall flux through a given pathway. In this case, glycogen breakdown and synthesis are regulated by: glycogen phosphorylase and glycogen synthase, respectively: these enzymes are controlled both by: allosteric regulation, covalent regulation by phosphorylation.

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