BIOCHEM 3H03 Lecture 8: 6. Salicylate Toxicity

• School: McMaster University
• Department: Biochemistry
• Course: BIOCHEM 3H03
• Professor: Stephen Hill

Document Summary

Salicylate toxicity - interesting example of mixed acid-base disorders. Common analgesic (pain control), anti-inflammatory, anti-platelet (prevent cardiovascular disease- used in prevention of coronary artery disease) Acute toxicity may be intentional or not. Chronic toxicity - usually unintentional (if you use it for long periods of time) Uncouples oxidative metabolism: reduced atp, increased glycolysis, increased peripheral demand, fever and vomiting. Mixed acid base disorder: respiratory alkalosis and metabolic acidosis, both are primary disorders. Effects on intermediary metabolism increased glycolysis increasing fatty acid break down increase in ketones. Respiratory stimulation breathing harder lost more water from respiration, leading to electrolyte imbalance. Uncoupling of oxphos tr(cid:455)i(cid:374)g to use (cid:373)ore o(cid:454)(cid:455)ge(cid:374) (cid:271)ut (cid:455)ou (cid:272)a(cid:374)"t (cid:373)ake atp increased oxygen consumption and co2 production. I(cid:374)(cid:272)reased de(cid:373)a(cid:374)d for atp (cid:455)ou (cid:272)a(cid:374)"t (cid:373)ake - hard to know whether hypo or hyperglycaemia will be predominate: hyperpyrexia hot, sweating lose water that way.