HTHSCI 2H03 Lecture Notes - Lecture 10: Coronary Circulation, Angina Pectoris, Hypotension
24 May 2016
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Document Summary
Relax coronary arteries and venous smooth muscle. Decreases the amount of blood returning to the heart. Dilates arterial smooth muscle, which increases blood flow to myocardium and improves oxygen supply to myocardium. First line therapy for terminating an angina attack. ** greater effect on healthy coronary arteries if they are not riddled with plaque, they will be more responsive - if they are, it is not likely we will be able to dilate these vessels adequately. Risk of hypotension in the dilation of veins. Vasodilation and decreased blood flow cause adverse effects. Caution in those with liver and kidney disease. Caution in those with hypotension, hypovolemia, and pre- existing conditions that limit co. Heparin, drugs for treatment for erectile dysfunction (already cause vasodilation) Use caution in those with asthma, copd (use cardioselective) Related to inhibition of sympathetic division of ans. Rapid withdrawal can worsen angina slow withdrawal, or we could end up with rapid hr and increase risk of mi.
