HTHSCI 3I03 Lecture Notes - Pathogen-Associated Molecular Pattern, Heat Shock Protein, Tlr2
16 Mar 2013
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Note: sterile infection= when the bodys own cells are all dying for example. Pamps= pathogen associated molecular patterns (ligand: not on host cells (therefore microbial pathogens, small number of receptors for a large number of pathogens, pamps= key to their survival, common/invariant structures. Damps= danger associated molecule: hmgb- high mobility box group= stabilizes chromatin, hsp= heat shock protein, atp, uric acid. Receptors: phagocytic receptors (cause phagocytosis) and pattern recognition receptors: phagocytic= no signaling= mannose receptor, scavenger receptor, complement receptor, pattern receptors= nlr (nod-like receptor), nalp, toll-like receptor, mannose binding. Myd88= activated= induces transcription of inflammatory cytokines (tnf , il-6, il-1 . Trif (more limited to tlr3 and tlr4)= increases transcription of type 1 interferon (ifn and. Tlr2/tlr6 and tlr1/tlr2 = called tlr2 mediated signaling = on cell surface. Note: tlr2 cannot signal alone= once activated= dimerizes with either tlr6 or tlr1. Tlr5, tlr 4 and tlr 11 also found on the membrane.
