KINESIOL 2Y03 Lecture Notes - Lecture 2: Zona Pellucida, Polyspermy, Zp3

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Embryonic period - fertilization to the end of the 8th week, organ systems develop. Germinal period - first 2 weeks of development during formation of primitive germ layers. Fetal period - 9th week until birth, organ systems grow and mature. Step 1 - multiple sperm cells penetrate the corona radiata of the secondary oocyte. Step 2 - zona pellucida has zp3 glycoprotein (sperm receptors that are species specific) Step 3 - acrosomal reaction (happens at the tip of the sperm head called the. Step 4 - one sperm binds to integrin a6b1 (located on the oocyte plasma membrane) and causes depolarization. Intracellular release of ca2+ exocytosis of h2o oocyte shrinks zona pellucida denatures zp3 becomes inactivated. Step 5 - female nucleus undergoes second meiotic division (forms ovum and second polar body) Step 6 - female pronucleus & male pronucleus form. Clinical/medical events - date since last menstrual period (clinical age of unborn child)

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