MEDRADSC 3C03 Lecture Notes - Lecture 10: Hypertensive Crisis, Aldosterone, Loose Connective Tissue

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Function: cortex secretes 3 main hormones, aldosterone: regulates fluid volume and blood pressure. Increased aldosterone can increase bp and cause hypertension: cortisol: production increases with stress. Increased stress increases production: androgens: hormone stimulation, affects production of testosterone, masculization of females can occur with abnormal levels. Inner medulla secrete catecholamine"s: epinephrine and norepinephrine, can restricts blood flow, if tumor is secreted by a tumor and we puncture it we could risk increasing adrenaline in the body. Pheochromocytoma: most likely found in adults, make up 90% of adrenal (hyper functioning) tumors, secrete norepinephrine and epinephrine. Malignant neoplasms: lymphoma, non-hodgkin disease, mets, 4th most common site after lung liver and bone, adrenocortical carcinomas, rare primary malignancy, hyper functioning (usually) or non-functioning, poor prognosis/survival (30% in first 5years of diagnosis) Hyper functioning tumours: patients present with, headache, high bp, tachycardia, weight loss, diaphoresis, anxiety, virilization androgens of females. Pre procedure: patient history and screening, inr, ptt, vma.

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