BCHM 102 Lecture Notes - Lecture 11: Cori Cycle, Glycogenin, Phosphorylase
2 Dec 2016
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Discuss gluconeogenesis and how it differs from a simple reversal of glycolysis. Describe glycogen metabolism and how glucose is stored (glucagon) and subsequently mobilized in times of need. Apply an understanding of these pathways to glucose homeostasis. Anabolic pathway converting pyruvate (or lactate) to glucose. Occurs partially in mitochondria and partially in cytoplasm of liver and kidneys. Not a simple reversal of glycolysis: glycolysis favours for formation of pyruvate, need to work around irreversible steps of glycolysis. Include all intermediates of glycolysis and the tca cycle. Most important substrates are: glycerol from the breakdown of lipids (fats, lactate released into blood from red blood cells and exercising muscles, amino acids released from breakdown of proteins and converted into. This only occurs in the liver, and a little bit in the kidneys. Glucose from blood is taken up by intensely exercising skeletal muscle. Lactate diffuses to blood and taken up by the liver.
