PHAR 340 Lecture Notes - Lecture 16: Vasoactive Intestinal Peptide, Neurotransmission, Skeletal Muscle
23 Dec 2018
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Document Summary
Multiple release sites per axon in ans + multiple transmitters released from autonomic varicosities. Postjunctional rs for ach: nicotinic for nmj (skeletal), muscarinic for smooth (auto) Ne, npy and atp from symp vasoconstrictor neurons. Ach and substance p from enteric excitatory motor neurons. Atp and vasoactive intestinal peptide from enteric inhib motor neurons. Serotonin and ach at interneuronal synapses in ens. Nerve impulse memb depol opens chans + incr intra ca ca entry synaptic vesicle exocytosis (ca dependent process) diff of nt across neuroeffector junction act of nt r depol of postgang or response of effector cell. Choline brought in via cht + binds acecoa cat by chat ach packaged into vesicle via vat chem trigger (ca depol) release of vesicle broken down or autoreg via. Hemicholiniums: inhibit trans of choline into cell. Vesamicol: blocks packaging of ach in vesicles. Botulism: blocks exocytosis release of ach (relaxes skeletal muscle)
