PHAR 340 Lecture Notes - Lecture 17: Neuromuscular Junction, Adrenal Medulla, Cholinergic
23 Dec 2018
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Nicotinic: ligand gated chan provides hydrophilic pathway, perm to na and some ca, 5 alpha subunits around central pore, undergo rapid desens. Nn: ganglionic, trans b/n pre and postgang neurons and to adrenal medulla which releases e (sns + pns) Mediated by postsynaptic nicotinic r act, leads to memb potential depol (epsp) If threshold is reached post synaptic cell conducts ap into axon terminals and release nt, postsynaptic m1 r are also excitatory. Vascular effects: binds m3 r on endothelium incr intra ca act no synthase (nos) releases no smooth cells + act soluble guanyl cyclase incr cgmp + relaxes muscle (inhibitory bc it only binds endothelia not smooth muscle) Gut effects: causes vasodilation, contraction in circ and long smooth muscle (gq/11 ip3 ca), chloride secretion (gq/11 in enterocytes ca act cl chans) Metabolic rs aka gpcr-gtp binding proteins, heterotrimeric r-, serpentine r.
