MBB 231 Lecture Notes - Lecture 17: Sister Chromatids, Nuclear Pore, Prometaphase
16 Apr 2016
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At the end of this secion you should. Know the four stages of the cell cycle and what occurs during each stage. G1- gap phase before the iniiaion of dna synth. S- duplicate all the dna in the cells chromosome. G2- gap phase in which the cell contains twice the number in g1 cells. M-segregate the copies into 2 daughter cells: understand the meaning of go. Resing phase, no cell division: be familiar with the stages of mitosis and what is occurring at each stage. Prophase- chromosomes are condensed, mtoc forms, nucleaion and elongaion of microtubules. Prometaphase- nuclear envelope breakdown, chromosomes atach to microtubules via kinetochore. Phosphorylaion of speciic nucleoporins causes nuclear pore complexes to dissociate during prometaphase. Phosphorylaion of inner nuclear membrane proteins (inms) inhibits their interacion with lamins and with chromain. Phosphorylaion of chromain proteins induces chromain condensaion and inhibits interacions between chromain and the nuclear envelope. Anaphase- sister chromaids synchronously separate to form two daughter chromosomes.
