PSYCO403 Lecture Notes - Lecture 7: Apolipoprotein E, Zygosity, Allele
22 Mar 2020
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Document Summary
Begins with a phenotype group and compares clinical group with control group. Variation at a single position in a sna sequence. The 2 alleles that differ reflect a genotype of interest. Heterozygote carrier of two different alleles (hh) Three alleles produce homozygote variants and three heterozygote variants. Refers to the possibility that genetic differences cause some of the variation in these two phenotypes that is manifested in humans. Three approaches to examining genetics and cognitive aging. Issue it looks at too many genes (very broad approach) Strengths specificity, mechanisms, prediction of phenotypes and transitions. Weakness too narrow, only looks at 1 gene, however, genes interact. Searching for intensification or magnification or moderation of genetic risk on ad. Strengths possible enhanced prediction of preclinical change and transitions and ad conversion. Allows for precision prescriptions (tailored specifically to an individual) Ex. if you have type 2 diabetes and apoe e4 gene.
