PHRM 311 Lecture Notes - Lecture 14: Electrical Resistance And Conductance, Ion, Felbamate
Document Summary
Special aspects of pk for the brain (part 1) Getting to the correct part of the brain. Genome variability polymorphisms leading to alterations in. Ineffective mechanisms of drug action (e. g. change in receptor number, density) To understand how the blood:brain barrier limits access to the brain and strategies to get drugs into the brain. Maintained by the capillary network supplying blood to the brain the blood-brain barrier (bbb). Capillary endothelial cells in the brain are different to those found in peripheral tissues: Brain endothelial cells are joined by tight junctions of high electrical resistance providing an effective barrier against paracellular movement of molecules. In peripheral endothelial cells , there is good transcellular movement of molecules (no such movement in brain endothelial cells) Brain capillaries are in contact with ends of the astrocytes , which essentially separate the capillaries from the neurones. The bbb is both physical and a delicately balanced set of transport mechanisms.
