BIO 1140 Lecture Notes - Lecture 22: Telomerase, Oncogene, Kinesin
8 Oct 2016
School
Department
Course
Professor
Document Summary
Mpf= maturation promoting factor = cyclin + cdk complex. Cyclins are going up and down during the cell cycle. When they peak they are at the highest concentration and this is where you have a maximum combo with the cdk, so your activity to move forward is at a max. The combo of cyclin and cdk mpf. Mpf cyclin and cdk bound together. Only are active when they are bound to their respective cyclins; ubiquitin will degrade lysosome; mitophagy is also dependent on these, similar process but different target. They are named according to the checkpoint they govern: G1/s cyclins (e): bind their cdk (2) near end of g1 and lead cell into dna replication. S cyclins (a): bind their cdk (2) during s phase and are required for dna replication. M-cyclins (a, b): bind cdk (1) to promote the events of mitosis.
