BIO 3124 Lecture Notes - Lecture 12: M1 Protein, Lipid A, Immunogenicity
7 Dec 2017
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Open book, multiple choice thursday november 23rd 2017 8:30 am. Consequences: treatment of an invading organism could save a life, you establish a selective pressure. Invading microorganisms must develop resistance or it will die: fleming warned that inappropriate use of antibiotics will lead to the selection of resistant bacteria, a few years later, the first resistant strains appeared. Reasons for high consumption: patient, wants rapid treatment, physician, wants to satisfy patient, avoid legal proceedings for malpractice. Industry: wants to make money, pressure from pharma companies. Innate resistance: resistance is not acquired; natural trait. Streptomycetes resistant to the antibiotic: gram negative bacteria with permeability barrier, bacteria that do not possess the antibiotic targe. Acquired resistance: microorganism acquires a resistance to one or more antibiotics, typically, after the administration of a given antibiotic or antibiotics with similar structures/properties. Impermeability: reduced number of porins, reduce the amount of molecules entering cell, biofilms, block entering of foreign.
