PHA 4107 Lecture Notes - Lecture 14: Vinca Alkaloid, Gemcitabine, Etoposide
12 Jul 2018
School
Department
Course
Professor
Document Summary
Cancer therapies mostly target proliferative cells cells even when the cells are not dividing: not always proliferative cells, for that reason some chemo are actually able to interfere with function of. In many tumors, there aren"t a lot of cells that are dividing. It attaches the alkyl group to the guanines on opposite strands at the number. Prototype alkylating agent: cyclophosphamide: bis(chlorethyl)amine: cyclophosphamide is metabolized by cyt p450 first to hydroxylated intermediates and then to the active phosphoramide mustard, wide application: lymphomas, leukemias, some neuronal cancers, side effects: > resistance because are multi clonal and can change over time increased repair activity decreased cell permeability glutathione-mediated reduction. Antimetabolites: mechanisms of action are based on the structures of the drugs which are closely related to the normal molecules made by the body and therefore interfere with normal processes, 2 classes: Interfere with enzyme called thymidylate synthase which is a transfer of methyl group: methotrexate (mtx):
