BIOC13H3 Lecture Notes - Lecture 15: Uncoupling Protein, Atp Synthase, Electrochemical Gradient

40 views4 pages
17 Apr 2017
School
Course
Professor

Document Summary

Uncoupling means no longer nadh oxidation with atp synthesis. Uncoupling agents can be used for weight loss, but if not used controllably they can lead to too much weight loss and death. We have known how they work from like the first world war. They want a proton gradient to have as a source of energy to make atp. Even when mitochondria are resting (not producing atp) they have their proton gradient at its highest. When we give the mitochondria adp and pi, that"s when the magnitude of the proton gradient starts to drop, that"s because the protons are going through the channels. In reality the mitochondria always wants its proton gradient to be high so as it starts making atp, and the gradient goes down, then you need to start oxidizing more nadh to try to build that gradient back up.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents

Related Questions