HMB200H1 Lecture Notes - Lecture 11: Neural Tube, Habituation, Fear Conditioning
Document Summary
Lecture notes: neurobiology and intense world theory of autism. Recall that this is implicated in autism and inc inhibitory synaptic transmission in mice. Substitution in neuroligin-3 alters a conserved residue in the ec esterase-homology domain of neuroligin-3 in the swedish family. This is a single mutation found in two people in the world that have autism and it was subsequently found in mice. We need to broaden definition of mutations to a collection of variance that exists in many. One that is causing it, or a combination of the two --> disorder results. Many conditions of the brain requires many genes. Provides first mouse model (with identical genetics) --> very important. R451c enhances gaba signaling (greater inhibition in adult, but greater depolarization in young animals) Gaba shift: as cl increases, gaba responses become more inhibitory. Greater depol in young animals because of the cl concentration difference in juveniles. Provides means to test therapies (pharmacological or behavioural)
