IMM250H1 Lecture Notes - Lecture 2: Bacteroidetes, Streptococcus, Gastritis
Document Summary
Imm250 lecture 1 innate barriers: overview, mucosa body surface potentially exposed to the environment and different microbes, different types of barriers protecting us from these organisms, epithelial cells which binds the different mucosal surfaces. First line of cells which encounters pathogens: commensal microbiota , pathogen, two examples of pathogens, salmonella typhimurium, shigella flexneri. Innate barriers if invaded and infected innate immunity is activated: skin and mucosa membranes, humoral and cellular defenses different proteins and cells involved in protecting us from the body from pathogens. Inflammation: adaptive immunity consequence of activating the innate immunity, adaptive immunity is primed. Drives the stuff upwards: stomach low ph of 2. There"s an extremely rapid turnover of the epithelium cells lining the intestinal tract. Normal microbiota we have in our skin, upper airway gastrointestinal tract, respiratory tract, urogenital tract. It"s a very important factor in human surfaces. Some bacteria species are only transient, mostly are permanent.
