PSL301H1 Lecture Notes - Lecture 23: Supraoptic Nucleus, Aquaporin 2, Posterior Pituitary
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PSL301H1 Full Course Notes
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2. 2l intake +. 3l metabolism 1. 5l urine excretion, 0. 9l insensible loss. 0. 1l feces loss = 0l: proximal -70, loop 15, dct + cd 15% Ap -> pvn and son -> posterior pituitary: reduction in cell volume in response to low water, ca2+ channels open, depolarization, ap. Bone fracture in head as it is surrounded by bone. Gulping water is more thirst quenching than sipping: sodium leaves ascending loop but not water, water leaves descending loop but not sodium, back and forth until gradient established of 300mosm in cortex and 122mosm in medullar of kidneys. Gpcr -> camp -pka -> transcription of aqp2.
