Biochemistry 2280A Lecture Notes - Lecture 10: Inner Mitochondrial Membrane, Acetyl-Coa, Inner Membrane
27 Mar 2019
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Topic 10: acetyl-coa i: the citric acid cycle. Lipid bilayer: embedded in it are pores; not just small channels they are big pores, they make big holes in the mitochondrial membrane. If you"re a small molecule you can pass through pores small means 5000 daltons: proteins are larger than this; they won"t pass through. Inner membrane has much tighter regulation of what"s going in and out: doesn"t have pores in it; does have proteins however. Impermeable to small molecules unless they have some sort of a protein to help them get across. Inner membrane is also the one that"s folded in: these folds are called cristae, what the effect of this is is to increase the surface area of the inner mitochondrial membrane. Inner mitochondrial membrane has a much larger surface area than the outer membrane: this surface area is where all the actions happen in the mitochondria.
