Biochemistry 3381A Lecture Notes - Lecture 16: Acetyl-Coa, Cell Signaling, Mitogen

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 3381A
• Professor: Brian Shilton

Document Summary

Cell growth accumulation of biosynthetic mass to increase in cell mass and size. Examine signalling pathways leading to regulation of biosynthetic pathways. Nutrients are building blocks for all biosynthetic events. Separate signalling pathways which sense the level of nutrients and energy, acting together with growth factor and mitogen to activate certain processes which cause cell growth. Hormones/growth factors which bind to receptors to induce biosynthetic processes. Cell grow bigger and if needs to divide to produce 2 viable daughter cells: oncogenes, hormones, nutrients, growth factors, amp:atp. Transport of nutrients into the cell: receptor mediated endocytosis, phagocytosis, proteasomal degradation induced by coupling with ubiquitin, autophagy when cells do not have nutrients/energy, they attain energy from the inside. Use most nutritious cellular organelles such as mitochondria. Catabolise anything inside to induce pro-survival signalling pathways. Induced using the energy of nutrients: amino acid transporters regulated by signalling machines. Ion channels: glucose transporters nutrient receptors, nutrient receptors, ldl-r, tfr.