Biology 2382B Lecture Notes - Lecture 15: G Protein–Coupled Receptor, Steroid Hormone Receptor, Bacterial Effector Protein
24 Oct 2018
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Incredibly hot area of publishing over 300000 papers published: receptor tyrosine kinases (cid:523)rtk"s(cid:524, g-protein coupled receptors (cid:523)gpcr"s(cid:524, all aspects of normal development and physiology, major classes of signal transduction, proto-oncogenes (ras, mitogen activated protein kinases (mapk) Overview of cell signalling: ligand, generally hydrophilic, will bind to cell surface receptors, have ligand binding sites where the ligand binds, when the ligand binds to eh extracellular. Nuclear-receptor superfamily or in blood travels: lipid-soluble hormones bind to intracellular receptors which constitute the nuclear- receptor superfamily of transcription factors. If we look at the a. a opposition how similar are they if we look at all these receptors: this can be anywhere from 42-94% amino acid. So the dna binding domain of these receptors are highly conserved: the ligand binding domains are slightly less conservative and that may be related to the variances in the structures of these ligands. It is able to pass the plasma membrane and bind to the glucocorticoid receptor.
