Biology 2382B Lecture 9: Lecture 9-Cell_Signaling-2014
7 Jan 2019
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Lecture 9: basic principles of cell signalling and gpcr system. Involves growth factors, cytokines, hormones, ecm, neurotransmitters, light, sound, etc. Incredibly hot area; over 300,000 papers published: all aspects of normal development & physiology. Some of the players: receptor tyrosine kinases (rtk"s, g-protein coupled receptors (gpcr"s, proto-oncogenes (ras, mitogen activated protein kinases (mapk) Signal transduction getting a signal outside the cell and transmitting it into another signal that the cell can recognize and respond to. The major stimuli are ligands these ligands can be anything from proteins growth factors, cytokines, hormones, ecm proteins, neurotransmitters, light, sound, etc. Signal transduction has to work properly if it does not, a whole bunch of problems diseases such as cancer, heart disease, diabetes, degenerative diseases leads to disease: pharmaceuticals intervention are reliant on the manipulation of signal transduction pathways. Small molecules (epinephrine, acetylcholine, steroids), peptide hormones, monoamines etc. Large molecules, growth factors, cytokines (proteins: receptors, cell-surface receptors.
