Biology 2382B Lecture Notes - Lecture 9: Tyrosine Kinase, Signal Transduction, Cell Signaling
11 Apr 2018
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Lecture 15: basic principles of cell signaling and gpcr system. If signal transduction is not regulated properly it can initiate disease, such as cancer, heart disease and diabetes: some of the players, receptor tyrosine kinases (rtks, g-protein coupled receptors (gpcrs, proto-oncogenes (ras, mitogen activated protein kinases (mapk) Nuclear-receptor superfamily: the nuclear-receptor superfamily has a hydrophobic domain that allows them to transverse the plasma membrane and bind to intracellular receptors. In endocrine signaling you have one cell type producing a ligand (insulin) that enters the bloodstream and affects distant target cells. In paracrine signaling one cell produces the ligand and an adjacent cell responds to it: ex. presynaptic and postsynaptic neurons. Signaling by cell-surface receptors: synthesis and release the signaling molecule by the signaling cell, transport and binding the signal to a specific receptor of the target cell, which causes a conformational change.
