Biology 3316A/B Lecture Notes - Lecture 16: Mst1, Cilium, Primary Cell
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Hippo/mst1: hippo is to flies as the mammalian sterile is to us, hippo pathway is a kinase cascade, one needs to activate one in order to activate the next one, etc. All of these enzymes are sitting dormant, not doing anything, until their activation. Fly discovered that if you mutate hippo gene, there is uncontrolled cell growth. Cell density dictates whether you have an activate pathway or not: mst1 overexpression doesn"t do a proliferative effect. If you turn the overexpression off, that is when the liver goes back to normal size. Cell density dictates whether you have an active pathway or not. Signature for 14-3-3 to come along and keep it out of the nucleus. Cell density gets too high stop proliferation. If you don"t cells continue to proliferate and then they get to about 1 million cells and have to proliferate, otherwise, the internal part of the tumour will die. The livers don"t have the same number of cells!