Kinesiology 4430F/G Lecture Notes - Lecture 2: Glycogen, Glut4, Beta Oxidation
20 Dec 2017
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Key points: enzyme phosphorylation: a kinase adds a phosphate, a phosphatase removes a phosphate, adding or removing a phosphate can either activate or inactivate an enzyme. Image shows the function of a kinase and phosphatase. Protein kinase - phosphorylates an enzyme that carries a phosphate: turns enzyme on and activates it, signal produced. Protein phosphatase reverse effect: turns off enzyme, removes inorganic phosphate and inactivates the enzyme. By adding a phosphate, you can activate or inactivate the enzyme depending on what type it is. Pyruvate acetyl coa through pdh a produces co2: want these by-products for cac and etc. If you have ca+, that will have a positive effect on pdh phosphate removes inorganic phosphate and actives it. If you have high levels of pyruvate, want to run it through acetyl coa: affects the pdh kinase and downregulates the system to convert it to inactive form there is more than the system can handle.
