Kinesiology 4430F/G Lecture 11: 11 Exercise Training and Fat Metabolism
20 Dec 2017
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Cellular signaling and mitochondrial biogenesis in muscle: ampk and other stressors that occur while exercising induce mitochondrial biogenesis, exercising: muscle contraction produces cell signals such as increasing. Calcium, amp & ros: feedback through a chain of signals, these signals activate protein kinases, ampk, camk, goal: the ampk and other kinases activate pgc-1a, stimulating mitochondrial biogenesis (produce additional mitochondria) Muscle citrate synthase activity and glucose oxidation: data from 90min continuous cycling exercise @ 55% vo2 max. Individuals with varying training status": looking at muscle synthase activity relative to amount of cho (glucose, strong negative correlation between the 2 variables. If you had more synthase, less cho utilization: less mitochondrial capacity, the more glucose utilization. Looking at fa uptake and oxidation and relating them to had activity: b-had activity indicator of beta oxidation. If increasing mitochondrial content, increasing oxidative capacity = should be increasing b-had to metabolize fat into acetyl coa.
