Microbiology and Immunology 3300B Lecture Notes - Lecture 8: Cd154, Mhc Class Ii, White Pulp
9 Dec 2016
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Document Summary
Bcells with a normal repertoire but defective t-cell mediated immunity due to an extremely limited t-cell repertoire. When epithelial layer is infected by a virus, cytotoxicity is a good way to kill this cell. If this is a new virus never seen before, need innate recognition (nk cells recognize missing self) Viruses force cells to downregulate mhc class 1. Viruses like to attach epithelium inside the gut, the airways, etc. Complement doesn"t do as well with viruses, phagocytosis also doesn"t really work. Innate system also produces cytokines interferons interfere with viral replication. Innate system could also recognize a virus through prrs ones that recognize ss or. Difference between immature and mature dc ccr7 bring its to the t-cell zone, will ds dna or rna. Dcs are living around in the tissue, collecting antigen, when out in the tissue it is an immature dc, goal is to take up antigen, not active in presentation.
