Microbiology and Immunology 3820A Lecture Notes - Lecture 12: 1918 Flu Pandemic, Human Parainfluenza Viruses, Encephalitis Lethargica

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 3820A
• Professor: Kelly Summers

Document Summary

Respiratory infections: morbidity and mortality in humans respiratory system badly designed, cause about 80% of acute illnesses that result in a loss of time from work, ~80% of respiratory infections are viral. Influenza surface proteins: hemagglutinin, (cid:883)(cid:887) subtypes (cid:523)(cid:883), (cid:884), (cid:885) (cid:524, 9 subtypes (cid:523)(cid:883),(cid:884),(cid:885) (cid:524, neuraminidase, mediates budding off from the cell. ** influenza a has a combination of both. 2: spreads through human population, major antigenic change pandemic, random, can happen anywhere, pandemic strains usually replace previously circulating strains. Pandemic human influenza strains (cont. : (cid:884)(cid:882)(cid:882)(cid:891) ((cid:883)n(cid:883) (cid:498)(uman swine )nfluenza(cid:499, very mild illness, unlikely to mutate into virulent strain: no pb1-f2 protein, mainly infecting young persons, increased mortality in pregnant, replaced previous strains. Influenza prevention and rx: vaccines are inactivated whole virus or (cid:498)split virus(cid:499), composed mainly of, rapid tests for viral antigen in nasal secretions are widely available hemagglutinin antigens.